Hyaluronidase breaks down and helps the body reabsorb hyaluronic acid dermal fillers that were previously injected. Hyaluronidase is effective in doing this by increasing the permeability of tissues and breaking the molecular bonds within the hyaluronic acid while promoting cellular processes to diffuse the product.

What Is Hyaluronidase?

Hyaluronic acid (HA) is naturally produced and occurring substance found in the human body, formulations of this substance can be injected to add or restore/add volume, shape, sculpt and hydrate the skin. It can last from a few months to a year or more depending on the product and is very popular for lip injections or reducing the appearance of fine lines and wrinkles. However, sometimes a person may not be happy with the outcome or have a change of mind, luckily thanks to hyaluronidase and injection of this compound in the regions dermal fillers were previously injected can reverse the effect of the procedure. Hyaluronidase is also potentially useful if the patient has had a reaction to a HA-based filler.

Other Uses

Hyaluronidase has the useful ability to dissolve chemical agents making it an effective additive for local anesthetics because hyaluronidase allows an injected solution to more easily spread through the injection area and penetrate tissue which may even speed up the initial onset of the numbing effect when used in this way.

How Does This Work?

Hyaluronidase treatments are most typically suggested to patients who have previously had injections of HA-based fillers and either are looking to change or reverse the results of the procedure. When an enzyme solution of hyaluronidase is injected under the skin in a region that had previous hyaluronic acid fillers injected it can catalyze the body’s ability to break down, metabolize and reabsorb the filler product. Overall, the hyaluronidase does the opposite of a previous hyaluronic acid based filler treatment and returns a patient to their previous look as if the filler was never injected.

The Effectiveness of Hyaluronidase

One of the significant benefits of HA dermal fillers is that they can be easily reversed using hyaluronidase to dissolve the filler. This gives Cosmetic Doctors the ability to quickly correct injections and ensures patients satisfaction and safety. Before hyaluronidase started being used as a “reversal treatment” any errors or unsatisfied patient outcomes required them to wait for the metabolization and absorption of the filler over several months. Many studies have been done regarding the effectiveness of hyaluronidase as a catalyst assisting with dissolving HA and assisting the body in absorbing it rapidly, typically concluded that “the use of hyaluronidase reduced patient discomfort within 24 to 48 hours, deterring any patient anxiety or patient dissatisfaction.”. In a study published by the Journal Watch Dermatology in 2005, evidence of hyaluronidase’s ability to break down hyaluronic acid in dermal filler patients was recorded. The study saw a group of 12 volunteers who were injected with 0.2 mL of hyaluronic acid dermal filler in two separate areas of the arm, about 10 cm apart. A few days after they were injected, the test subjects were brought back to be injected with hyaluronidase and saline solution. Hyaluronidase was injected on one dermal filler site, while a saline solution was injected on the other. Four to seven days after the hyaluronidase solution injection, 80% of the hyaluronic acid gel had disappeared, while 90% of the hyaluronic acid gel injected with the saline solution had remained

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