Hyaluronidase breaks down and helps the body reabsorb HA dermal fillers previously injected. In addition, Hyaluronidase effectively increases the permeability of tissues and breaks the molecular bonds within the HA while promoting cellular processes to diffuse the product.


What Is Hyaluronidase?

HA is a naturally produced and occurring substance found in the human body. This substance can be injected to add or restore/add volume, shape, sculpt and hydrate the skin. It can last from a few months to a year or more depending on the product and is very popular for lip injections or reducing the appearance of fine lines and wrinkles. However, sometimes a person may not be happy with the outcome or have a change of mind. Luckily, the procedure can reverse thanks to Hyaluronidase and injection of this compound in the region’s dermal fillers previously injected. Hyaluronidase is also potentially useful if the patient has reacted to an HA-based fill.


Other Uses

Hyaluronidase can dissolve chemical agents, making it an effective additive for local anesthetics. In addition, Hyaluronidase allows an injected solution to more easily spread through the injection area and penetrate tissue, which may even speed up the initial onset of the numbing effect when used.


How Does This Work?

Hyaluronidase treatments are most typically suggested to patients who have previously had injections of HA-based fillers and are either looking to change or reverse the procedure results. When an enzyme solution of Hyaluronidase is injected under the skin in a region with previous HA fillers injected, it can catalyze the body’s ability to break down, metabolize and reabsorb the filler product. Overall, the Hyaluronidase does the opposite of a previous HA-based filler treatment and returns a patient to their last look as if the filler was never injected.


The Effectiveness of Hyaluronidase

One of the significant benefits of HA dermal fillers is that they can be easily reversed using Hyaluronidase to dissolve the filler. This enables Cosmetic Doctors to quickly correct injections and ensures patient’s satisfaction and safety. Before Hyaluronidase started being used as a “reversal treatment”, any errors or unsatisfied patient outcomes required them to wait for the metabolization and absorption of the filler over several months. Many studies have been done regarding the effectiveness of Hyaluronidase as a catalyst that assists with dissolving HA, and the body absorbs it rapidly. It Is said that “hyaluronidase reduces patient discomfort within 24 to 48 hours, deterring any patient anxiety or dissatisfaction.”. In a study published by the Journal Watch Dermatology in 2005, Hyaluronidase’s ability to break down HA in dermal filler patients was recorded. The study saw a group of 12 volunteers who were injected with 0.2 mL of HA dermal filler in two separate areas of the arm, about 10 cm apart. A few days after they were injected, the test subjects were brought back to be injected with Hyaluronidase and saline solution. Hyaluronidase was injected on one dermal filler site, while a saline solution was injected. Four to seven days after the hyaluronidase solution injection, 80% of the HA gel had disappeared, while 90% of the HA gel injected with the saline solution had remained.

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