Hyaluronidase is an enzyme that causes the degradation of hyaluronic acid filler to remove unwanted or overcorrected HA. It works by hydrolysing, in which it ruptures one or more chemical bonds. 

WHAT IS HYALURONIDASE?

Hyaluronic acid is a substance found in the body and is used as a main component in dermal fillers to hydrate the skin and restore volume. On the other hand, hyaluronidase is injected to speed up the process of reversing the effect of a dermal filler treatment as it dissolved chemical agents of the fillers. Hyaluronidase is also produced by our bodies to break down fillers over a period of time. So when it is injected on the lips, it allows the recovery of the lip’s natural shape faster. 

HOW DOES IT WORK?

If a person is dissatisfied with the results of the dermal fillers or if the patient has had a reaction to it, hyaluronidase treatment is typically suggested. Naturally, our bodies produce hyaluronidase and aids in absorbing hyaluronic acid fillers. Therefore, when hyaluronidase is injected in an area where hyaluronic acid filler was placed, it accelerates the body’s ability to chemically decompose the fillers as if no treatment ever took place. 

WHAT ARE THE BENEFITS OF HYALURONIDASE? 

In the past, reversing a treatment for fillers takes a long time of waiting. A patient usually wait several months until the fillers are absorbed in the body. Fortunately, hyaluronic acid fillers can be easily dissolved with the use of hyaluronidase. This allows cosmetic doctors to safely correct treatments and to reduce patient discomfort within 24 to 48 hours. 

In 2005, a study was published by the Journal Watch Dermatology about the ability of hyaluronidase to catalyze hyaluronic acid in dermal filler patients. In a group of 12 volunteers, half of the subjects injected with hyaluronidase had a success of 80% disappearance of fillers for 4 to 7 days while the remaining that was injected with saline, the hyaluronic acid gel stayed. 

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